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- Title
Citalopram improves vasomotor syndrome and urogenital syndrome of menopause in Mexican women: a randomized clinical trial.
- Authors
Rios-Espinosa, Alan; Cruz-Luna, Magdalena; Garmendia-Gallardo, Carolina; Hernández-Castañón, Merle Yasmin; Hernández-Hernández, Verónica Yazmin; Sánchez-Tinoco, Paula Mariana; Bajonero-Domínguez, Alma; Vergara Lope-Núñez, Jael Adrián; Álvarez-Pérez, Marco Antonio; González-Quiroz, José Luis; Loranca-Moreno, Patricia; Ocampo-Godínez, Juan Moises
- Abstract
Purpose: This study aimed to determine the efficacy of non-hormonal therapy with citalopram vs fluoxetine for treating vasomotor syndrome (VMS) and urogenital syndrome of menopause (GSM) in Mexican women. Methods: A parallel prospective randomized clinical trial was conducted in 91 postmenopausal women with a total score on the Menopause Rating Scale (MRS) ≥ 17 and with the clinical diagnosis of VSM and GSM. Patients were randomly assigned to receive citalopram (n = 49) or fluoxetine (n = 42). Follow-up was carried out at 3 and 6 months. Results: The citalopram group experienced a significant improvement compared to the fluoxetine group in the MRS total score (p < 0.01), as well as in the psychological (p < 0.001) and somatic (p < 0.0001) domains at 3 and 6 months of follow-up. After 6 months of follow-up, the group that received citalopram decreased the relative risk (RR) to present VMS symptoms (RR = 0.30, CI 0.19–0.5, p = 0.0001), depressed mood (RR = 0.31, CI 0.15–0.6, p = 0.0002), irritability (RR = 0.40, CI 0.22–0.73, p = 0.002), anxiety (RR = 0.30, CI 0.13–0.69, p = 0.003), physical and mental exhaustion (RR = 0.35, CI 0.18–0.67, p = 0.001), sexual problems (RR = 0.18, CI 0.06–0.48, p = 0.0001), vaginal dryness (RR = 0.34, CI 0.14–0.80, p = 0.01), and urinary problems (RR = 0.36, CI 0.14–0.92, p = 0.043). Conclusion: We conclude that citalopram tends to improve VSM and GSM symptoms in postmenopausal Mexican women. Thus, we recommend the daily use of citalopram 20 mg. However, further studies will be required to support the results of the present work. These should include a larger number of patients and a placebo group. Clinical Trial Registration: This clinical trial was retrospectively registered by the United States National Library of Medicine in the www.clinicaltrials.gov database on 04/20/2022. The given test Registration Number is NCT05346445.
- Publication
Archives of Gynecology & Obstetrics, 2022, Vol 306, Issue 6, p2035
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-022-06732-9