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- Title
Structural analysis of the yeast SWI/SNF chromatin remodeling complex.
- Authors
Smith, Corey L.; Horowitz-Scherer, Rachel; Flanagan, Joan F.; Woodcock, Christopher L.; Peterson, Craig L.
- Abstract
Elucidating the mechanism of ATP-dependent chromatin remodeling is one of the largest challenges in the field of gene regulation. One of the missing pieces in understanding this process is detailed structural information on the enzymes that catalyze the remodeling reactions. Here we use a combination of subunit radio-iodination and scanning transmission electron microscopy to determine the subunit stoichiometry and native molecular weight of the yeast SWI/SNF complex. We also report a three-dimensional reconstruction of yeast SWI/SNF derived from electron micrographs.
- Subjects
YEAST; ADENOSINE triphosphatase; CHROMATIN; GENETIC regulation; HYDROLYSIS
- Publication
Nature Structural Biology, 2003, Vol 10, Issue 2, p141
- ISSN
1072-8368
- Publication type
Article
- DOI
10.1038/nsb888