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- Title
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
- Authors
Barouch, Dan H.; Kunstman, Jennifer; Kuroda, Marcelo J.; Schmitz, Jörn E.; Santra, Sampa; Peyerl, Fred W.; Krivulka, Georgia R.; Beaudry, Kristin; Lifton, Michelle A.; Gorgone, Darci A.; Montefiori, David C.; Lewis, Mark G.; Wolinsky, Steven M.; Letvin, Norman L.
- Abstract
Shows that viral escape from cytotoxic T lymphocyte (CTL) recognition can result in the eventual failure of this partial immune protection. Description of viral mutations that escape from CTL recognition in HIV-infected persons and SIV-infected monkeys; Frequency of viral sequence mutations within CTL epitopes; Limitations of the CTL-based AIDS vaccines.
- Subjects
ANTINEOPLASTIC agents; MICROBIAL mutation; AIDS vaccines
- Publication
Nature, 2002, Vol 415, Issue 6869, p335
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/415335a