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- Title
Hypermethylation of Long Non-Coding RNA Genes Group in the Breast Cancer Development and Progression.
- Authors
Selezneva, A. D.; Filippova, E. A.; Lukina, S. S.; Pronina, I. V.; Ivanova, N. A.; Kazubskaya, T. P.; Burdennyy, A. M.; Braga, E. A.; Loginov, V. I.
- Abstract
We analyzed changes in the level of methylation of CpG islands in four long non-coding RNA (lncRNA) genes MEG3, ZNF667-AS1, GAS5, and SEMA3B-AS1 as promising markers of breast cancer. Methylation analysis was performed by quantitative methylation-specific PCR on a set of 38 paired (tumor/normal) breast cancer samples. Significantly (p<0.001) increased methylation was shown for three of the four lncRNA genes: MEG3, ZNF667-AS1, and SEMA3B-AS1. We found significant correlations of the methylation level of all the studied lncRNA genes with the stage of cancer and with lymphogenic metastasis, and for MEG3 and ZNF667-AS1 also with the tumor size. Methylation of ZNF667-AS1, and SEMA3B-AS1 genes in breast cancer was detected for the first time. Based on these findings, new potential markers for the diagnosis and prognosis of breast cancer can be proposed.
- Subjects
LINCRNA; BRCA genes; NON-coding RNA; CANCER invasiveness; CARCINOGENESIS; EPIGENOMICS; BREAST cancer prognosis
- Publication
Bulletin of Experimental Biology & Medicine, 2022, Vol 173, Issue 6, p765
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-022-05627-8