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- Title
Peculiarities of the Formation of Antimeningococcus Immunity in Mice Immunized with Fragments of N. meningitidis IgA1 Protease.
- Authors
Kotel’nikova, O. V.; Alliluev, A. P.; Zinchenko, A. A.; Prokopenko, Yu. A.; Zhigis, L. S.; Zueva, V. S.; Razgulyaeva, O. A.; Gordeeva, E. A.; Melikhova, T. D.; Nokel’, E. A.; Rumsh, L. D.
- Abstract
We studied immunogenicity of two recombinant proteins FR.9 and FR.11-3 created on the basis of fragments of the primary structure of N. meningitidis IgA1 protease with different molecular weights containing different sets of T and B epitopes. The proteins actively protect animals infected with live virulent culture of meningococci, serogroups A, B, and C. Analysis of CD4+, CD8+, and CD19+ lymphocyte populations in mouse blood showed predominant contribution of different cell populations to the formation of immune response to different proteins. Injection of FR.11-3 protein to animals did no affect the immunoregulatory index, hence, this protein can be used for creation of immunologically safe vaccine preparation.
- Subjects
NEISSERIA meningitidis; IMMUNOGENETICS; IMMUNOGLOBULIN A; RECOMBINANT proteins; CD4 antigen
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 6, p763
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4260-1