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- Title
Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia.
- Authors
Levchenkova, O.; Novikov, V.; Parfenov, E.; Kulagin, K.
- Abstract
We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum.
- Subjects
NEUROPROTECTIVE agents; HYPOXEMIA; CEREBRAL ischemia treatment; FREE radical reactions; OXIDATION; THERAPEUTICS
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 162, Issue 2, p211
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3578-9