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- Title
Modification of Human Fibroblast Properties in Microtransplant.
- Authors
Vishnyakova, Kh.; Popov, K.; Kudryavtseva, A.; Sadritdinova, A.; Snezhkina, A.; Tatosyan, K.; Bardashev, V.; Egorov, E.
- Abstract
We studied the properties of human skin fibroblast in filamentous polyglycolic microtransplant. Fibroblast adhesion to the microtransplant filaments is followed by the formation of a network cross-linked with fibroblasts. The cells rapidly proliferate during the first few days; after transfer of the microtransplant to the standard culture flask, the cells migrate to the plastic and continue proliferation. The cells are uniform and exhibit high colony-formation capacity. The bundles of microtransplant filaments persist in the culture for several days and through the cells completely leave them, the area around these filaments remains the most populated for 40 days. Mitotic cells are seen in the immediate proximity to the degrading filaments of the transplant. The effect of cell 'rejuvenation' in the microtransplant can be explained by selection of cells by their adhesion to relatively thin (about 15 μ) filaments, which excludes large old cells.
- Subjects
FIBROBLASTS; TRANSPLANTATION of organs, tissues, etc.; GLYCOLS; SKIN; CELL migration; CYTOPLASMIC filaments
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 157, Issue 1, p150
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2512-2