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- Title
The CRP Gene's Role in the Relations between Childhood Adversity and History of Suicide Attempts in Schizophrenia.
- Authors
Alfimova, M. V.; Lezheiko, T. V.; Gabaeva, M. V.; Plakunova, V. V.; Mikhailova, V. A.; Kaleda, V. G.; Golimbet, V. E.
- Abstract
Research suggests that, in contrast to circulating C-reactive protein (CRP), genetic variants conferring higher CRP levels have protective effects against schizophrenia and moderate influences of season of birth on the development of the disease. This study aimed to explore whether the CRP gene also moderates the relations between childhood adversity and clinical characteristics of schizophrenia. The relations between childhood adversity, genotypes at rs2794521 within the CRP locus, syndromes measured as five factors and two negative subfactors of the Positive and Negative Syndrome Scale, and history of suicide attempts were analyzed in 921 schizophrenia patients. A significant effect of genotype on suicide attempts in patients exposed to childhood adversity was found. The result suggests a moderating role of genetic determinants of inflammation in translating early life psychological stress effects into risk of suicide attempts in schizophrenia.
- Subjects
ATTEMPTED suicide; C-reactive protein; SUICIDE risk factors; GENETIC variation; SCHIZOPHRENIA
- Publication
Russian Journal of Genetics, 2023, Vol 59, Issue 2, p205
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795423020023