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- Title
Facile synthesis of ß-lactam derivatives by the Staudinger reaction using 3,6-dichlorotetrazine.
- Authors
Zarei, Maaroof; Salehinezhad, Aflatoon
- Abstract
A versatile and convenient method for synthesis of β-lactams using 3,6-dichlorotetrazine as an acid activator in the ketene-imine cycloaddition is reported. Monocyclic and spirocyclic β-lactams are obtained in good to excellent yields. Easy purification of the products can be performed by aqueous workup and then crystallisation from ethyl acetate.
- Subjects
LACTAM derivatives; TETRAZINE; RING formation (Chemistry); KETENES; IMINES; ETHYL acetate; CRYSTALLIZATION
- Publication
Journal of Chemical Research, 2015, Vol 39, Issue 12, p698
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751915X14473416848163