We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A convenient synthesis of 4-amino-2-fluoro-N-methyl-benzamide.
- Authors
Xu, Defeng; Xu, Xing; Zhu, Zhiling
- Abstract
A convenient and concise synthesis of 2-Fluoro-4-nitrobenzoic acid was obtained by oxidation of 2-fluoro-4-nitrotoluene with potassium permanganate in the presence of a phase transfer catalyst in 74% yield. N-methyl-2-fluoro-4-nitrobenzamide was then produced via chlorination and amination in 95% yield. Hydrogenation in the presence of Pd/C can afforded 4-amino-2-fluoro-N-methyl-benzamide in 98% yield
- Subjects
NITROBENZOIC acid; OXIDATION; NITROTOLUENE; POTASSIUM permanganate; PHASE-transfer catalysis; CHLORINATION; AMINATION; HYDROGENATION
- Publication
Journal of Chemical Research, 2013, Vol 37, Issue 10, p615
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751913X13787959772340