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- Title
Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production.
- Authors
Kim, Soo-Jung; Kim, Jin-Woo; Lee, Ye-Gi; Park, Yong-Cheol; Seo, Jin-Ho
- Abstract
Saccharomyces cerevisiae is a work horse for production of valuable biofuels and biochemicals including 2,3-butanediol (2,3-BDO), a platform chemical with wide industrial applications for synthetic rubber, biosolvents and food additives. Recently, a cutting-edge technology of metabolic engineering has enabled S. cerevisiae to produce 2,3-BDO with high yield and productivity. These include (i) amplification of the 2,3-BDO biosynthetic pathway, (ii) redirection of carbon flux from ethanol or glycerol toward 2,3-BDO, and (iii) 2,3-BDO production from sugars derived from renewable biomass. These breakthroughs enforced S. cerevisiae to become a promising microbial host for production of 2,3-BDO.
- Subjects
SACCHAROMYCES cerevisiae; PYRUVATE decarboxylase; BUTANEDIOL manufacturing; ACETOLACTATE synthase; BIOMASS energy; PHYSIOLOGY
- Publication
Applied Microbiology & Biotechnology, 2017, Vol 101, Issue 6, p2241
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-017-8172-1