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- Title
Induction of the zebrafish ventral brain floorplate requires cyclops/nodal signalling.
- Authors
Sampath, Karuna; Rubinstein, Amy L.; Cheng, Abby M. S.; Liang, Jennifer O.; Fekany, Kimberly; Solnica-Krezel, Lilianna; Korzh, Vladimir; Halpern, Marnie E.; Wright, Christopher V. E.
- Abstract
Reports that cyc (cyclops), in the zebrafish, encodes a transforming growth factor-beta (TGF-beta)-related intercellular signalling molecule that is similar to mouse nodal. How cyc is expressed in dorsal medendoderm at gastrulation and in the prechordal plate until early somitogenesis; Details of results indicating that cyc provides essential non-cell autonomous signal at gastrulation leading to induction of the floorplate and ventral brain.
- Subjects
ZEBRA danio; CYCLOPS (Crustaceans); TRANSFORMING growth factors-beta; GASTRULATION; ANATOMY
- Publication
Nature, 1998, Vol 395, Issue 6698, p185
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/26020