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- Title
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
- Authors
Pereira, Pedro Jose Barbosa; Bergner, Andreas; Macedo-Ribeiro, Sandra; Huber, Robert; Matschiner, Gabriele; Fritz, Hans; Sommerhoff, Christian P.; Bode, Wolfram
- Abstract
Presents research which studied the crystal structure of human beta-tryptase in a complex with 4-amidinophenyl pyruvic acid. What human tryptase is; Human tryptase's unique aspects; Crystal's monomers; Four active centers of the crystal's tetramer; Heparin chains; Implications of structure for biochemistry and the design of tryptase inhibitors.
- Subjects
SERINE proteinases; PYRUVIC acid; TETRAMERS (Oligomers); CHEMICAL structure
- Publication
Nature, 1998, Vol 392, Issue 6673, p306
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/32703