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- Title
In Vitro Effects of Sporobacterin Probiotic on the Function of Donor Granulocyte-Macrophage Cells.
- Authors
Gabrielyan, N.; Suskova, V.; Suskov, S.; Vologodskaya, N.
- Abstract
The effects of sporobacterin probiotic (Bakoren Company) on oxidative activity of donor granulocyte-macrophage cells (GMC) were studied in vitro by luminol-dependent chemiluminescent method, and the effects of the probiotic on the production of pro- and anti-infl ammatory cytokines were evaluated by ELISA. The probiotic dose-dependently stimulated spontaneous production of free radicals by GMC; combined treatment with immunomodulators likopid, polyoxydonium, and IFN-α2a produced a more potent effect. Sporobacterin stimulated the production of pro- and anti-infl ammatory cytokines in cell cultures. These data confi rmed the immunomodulatory effect of sporobacterin, an important component in the phagocytic system cells.
- Subjects
PROBIOTICS; PHYSIOLOGICAL effects of cytokines; MACROPHAGES; GRANULOCYTES; EXPERIMENTAL pharmacology
- Publication
Bulletin of Experimental Biology & Medicine, 2012, Vol 153, Issue 5, p697
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-012-1802-9