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- Title
Effect of antibiotics on implant failure and postoperative infection.
- Authors
Bafail, Arwa S; Alamri, Ahmed M; Spivakovsky, Silvia
- Abstract
Data sourcesMedline and hand search of the British Journal of Oral and Maxillofacial Surgery, Clinical Implant Dentistry and Related Research, Clinical Oral Investigations, Clinical Oral Implants Research, European Journal of Oral Implantology, Implant Dentistry, International Journal of Oral and Maxillofacial Implants, International Journal of Oral and Maxillofacial Surgery, Journal of Clinical Periodontology, Journal of Oral Implantology, Journal of Oral and Maxillofacial Surgery, Journal of Periodontology Medicina Oral, Patologa Oral y Cirugía Bucal, and Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology.Study selectionSearch of the literature was made to identify randomised controlled trials (RCTs) on the efficacy of antibiotics compared with a control group (not receiving antibiotics or receiving placebo.Data extraction and synthesisAll articles selected from the electronic and manual searches were independently assessed by the first and second authors of this study, in accordance with the established inclusion criteria. Two reviewers independently and in duplicate evaluated the quality of the included RCTs as part of the data extraction process.ResultsFour RCTs were included in the final review. These four RCTs grouped a total of 2063 implants and a total of 1002 patients.ConclusionsAntibiotic use significantly lowered the implant failure rate (P = 0.003), with an odds ratio of 0.331, implying that antibiotic treatment reduced the odds of failure by 66.9%. The number needed to treat (NNT) to prevent one patient from having an implant failure was 48 (95% confidence interval 31-109). In contrast, antibiotic use did not significantly reduce the incidence of postoperative infection (P = 0.754). Based on the results of this meta-analysis, and pending further research in the field, it can be concluded that there is evidence in favour of systematic antibiotic use in patients receiving dental implants, since such treatment significantly reduces implant failure. In contrast, antibiotic use does not exert a significant preventive effect against postoperative infection.
- Subjects
PHYSIOLOGICAL effects of antibiotics; DENTAL implant complications; SURGICAL complications; RANDOMIZED controlled trials; INFECTION prevention
- Publication
Evidence-Based Dentistry, 2014, Vol 15, Issue 2, p58
- ISSN
1462-0049
- Publication type
Article
- DOI
10.1038/sj.ebd.6401030