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- Title
THE HISTOPATHOLOGICAL CHANGES OF DIGOXIN ON MICE VITAL ORGANS.
- Authors
Jaafar, Farrah R.; Yahya, Nibras Zeyad; Humadi, Anas A.
- Abstract
The aim of this study was investigating to detriment the toxic effects of digoxin on the vital organs of mice like heart, Brain, liver, and kidneys. The experimental animals were categorized into 3 groups (T1, T2& C) each consist of 10 mice divided according to daily treatment with digoxin. T1, T2 groups representing dosing orally with 5, 10 mcg/ kg, respectively. C group acts as a control and treated with distilled water for 21 days. After a study period, animals were sacrificed. Histological samples were prepared by using hematoxylin and eosin stain. The study results of the T1 group show that different effects in liver tissue: degeneration signs, necrosis, low to severe periportal fibrosis and appear septal fibrosis. In Brain samples, perineural oedema with mild ganglion cell degeneration was clear. Kidney slices show enlargement of Bowman space with shrinkage of glomerular tuft and vacuolation of epithelia of lining urinary tubules. The T2 study group: brain slices present perineural and vascular edema, severe ganglion cell degeneration and necrosis. The renal tissue appears few infiltrations of inflammatory cells and vacuolation of urinary tubules. The main histological changes of Heart slices in both groups (T1, T2) were hemorrhage with oedema but the severity of lesion in T2 was higher characterized by hemorrhage with oedema and hyalinization of the myocardium. In conclusion, this study revealed that the digoxin of both doses: 5 mcg/kg and10 mcg/kg has histopathological effects in different vital organs of mice like (liver, brain, kidney and heart tissue), but these effects were severe in T2 group.
- Subjects
DIGOXIN; HISTOPATHOLOGY; URINARY organ physiology; HEMORRHAGE; NECROSIS
- Publication
Biochemical & Cellular Archives, 2019, Vol 19, Issue 2, p3147
- ISSN
0972-5075
- Publication type
Article
- DOI
10.35124/bca.2019.19.2.3147