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- Title
RecQ helicases: multifunctional genome caretakers.
- Authors
Chu, Wai Kit; Hickson, Ian D.
- Abstract
Around 1% of the open reading frames in the human genome encode predicted DNA and RNA helicases. One highly conserved group of DNA helicases is the RecQ family. Genetic defects in three of the five human RecQ helicases, BLM, WRN and RECQ4, give rise to defined syndromes associated with cancer predisposition, some features of premature ageing and chromosomal instability. In recent years, there has been a tremendous advance in our understanding of the cellular functions of individual RecQ helicases. In this Review, we discuss how these proteins might suppress genomic rearrangements, and therefore function as 'caretaker' tumour suppressors.
- Subjects
HUMAN gene mapping; DNA helicases; RNA; TUMOR suppressor genes; HUMAN genome; GENOMICS; TUMOR prevention; RESEARCH; ONCOGENES; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; HYDROLASES; COMPARATIVE studies; GENES; TUMORS
- Publication
Nature Reviews Cancer, 2009, Vol 9, Issue 9, p644
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc2682