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- Title
PSVII-19 Potential biomarkers of intestinal injury and inflammation in nursery pigs fed prebiotics.
- Authors
Andres, Joice V San; Sambeek, Dana van; Kinstler, Sydney; Trenhaile-Gannemann, Melanie; Winkel, Shana; Schlageter-Tello, Andres; Miller, Phillip; Burkey, Thomas E
- Abstract
Prebiotics may alter protein fermentation and reduce biogenic amines that cause intestinal injury and inflammation. Biochemical markers are important in assessing gut integrity and inflammation, especially in evaluating efficacy of interventions for intestinal health at weaning. The objective of this study was to determine the effects of weaning and dietary prebiotics on potential biomarkers of intestinal barrier integrity and immunity. Sixty-four pigs (21 d; BW 6 ± 0.5 kg) of mixed sex were used to test 4 dietary treatments with 4 pens per treatment and 4 pigs per pen. Pens were randomly allocated to 1 of the 4 diets following completely randomized design in a 2-phase 28-d feeding experiment. Dietary treatments were corn-soybean based diet (Control), Control + fructooligosaccharide (FOS), Control + chicory pulp (PC) and Control + sugar beet pulp + (SBP). Prebiotics were incorporated in the diet by partially replacing corn at rate of 0.05 and 0.1% in phase 1 and 2, respectively. Blood samples were collected from 2 pigs per treatment on d 0, 14 and 28 and analyzed for concentrations of tight junction protein 1 (TJP1), intestinal fatty acid binding protein (IFABP), and diamine oxidase (DAO). Dietary treatments had no effect on growth performance. The TJP1 concentration increased with time (P < 0.001). The DAO and IFABP concentrations decreased (P < 0.001) over time. Pigs fed FOS and PC had lower concentrations of DAO (P = 0.034) and IFABP (P = 0.043) than Control and SBP at d 14. Results show that TJP1, DAO, and IFABP serum concentrations vary over the weaning period which may be indicative of intestinal restitution in response to weaning stress. Moreover, inclusion of prebiotics in the diet may affect serum biomarkers which may support the inclusion of prebiotics to improve gut health in weaned pigs.
- Subjects
INTESTINAL injuries; BIOMARKERS; SWINE housing; CARRIER proteins; SUGAR beets; BIOGENIC amines
- Publication
Journal of Animal Science, 2019, Vol 97, p220
- ISSN
0021-8812
- Publication type
Article
- DOI
10.1093/jas/skz122.388