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- Title
Dexamethasone-eluting Vascular Stents.
- Authors
Hämäläinen, Mari; Nieminen, Riina; Uurto, Ilkka; Salenius, Juha‐Pekka; Kellomäki, Minna; Mikkonen, Joonas; Kotsar, Andres; Isotalo, Taina; LJ, Teuvo Tammela; Talja, Martti; Moilanen, Eeva
- Abstract
Percutaneous transluminal angioplasty ( PTA) with stenting is widely used in the treatment of vascular disorders, but restenosis remains a significant problem. Drug-eluting stents ( DES) have been developed as an attempt to reduce the intimal response leading to restenosis. Drugs used in DES include mainly immunosuppressive and anti-proliferative compounds. Glucocorticoids are also an interesting possibility for those purposes because they have anti-proliferative effects in vascular smooth muscle cells and down-regulate the production of cytokines and growth factors driving inflammation and fibrosis. In this MiniReview, feasibility and safety of drug-eluting metal and biodegradable vascular stents are discussed with special emphasis on dexamethasone-eluting stents.
- Subjects
DEXAMETHASONE; TRANSLUMINAL angioplasty; DRUG-eluting stents; GLUCOCORTICOIDS; IMMUNOSUPPRESSION
- Publication
Basic & Clinical Pharmacology & Toxicology, 2013, Vol 112, Issue 5, p296
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12056