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- Title
Down Sendromlu Çocuklarda Hematolojik Maligniteler: Geçici Lösemi ve Akut Megakaryoblastik Lösemi.
- Authors
Atik, Tahir; Siviş, Zuhal Önder; Karadaş, Nihal; Rashnonejad, Afrooz; Atikan, Başak Yıldız; Karapınar, Deniz Yılmaz; Vardar, Fadıl; Çoğulu, Özgür; Özkınay, Ferda
- Abstract
Down Syndrome (DS) is an important genetic disease resulting from partial or total trisomy of chromosome 21 and characterized by dysmorphic facial features, intellectual disabilities and multiple congenital anomalies. Children with DS are at increased risk of developing leukemia. Specifically, 3-10% of newborns with DS are diagnosed with transient myeloproliferative disease, and children with DS are 500 times more likely to develop acute megakaryoblastic leukemia (AMKL), and 20 times more likely to develop acute lymphoblastic leukemia (ALL) than children without DS. In this study, we report two children with DS presented with transient myeloproliferative disease.
- Publication
Journal of Pediatric Research, 2015, Vol 2, Issue 1, p46
- ISSN
2147-9445
- Publication type
Article
- DOI
10.4274/jpr.27146