We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical Constituents from Streblus taxoides Wood with Their Antibacterial and Antityrosinase Activities Plus in Silico Study.
- Authors
Parndaeng, Kedsaraporn; Pitakbut, Thanet; Wattanapiromsakul, Chatchai; Hwang, Jae Sung; Udomuksorn, Wandee; Dej-adisai, Sukanya
- Abstract
Hyperpigmentation frequently occurs after inflammation from bacterial infection. Thus, the inhibition activity of tyrosinase, the key enzyme to catalyze the melanogenesis and/or inhibition of bacterial infection, could decrease melanin production. Hence, the potential inhibitors could be discovered from natural products. ω-Hydroxymoracin C (1), a new compound with two other 2-arylbenzofurans, i.e., moracin M (2) and moracin C (3), and two stilbenes, i.e., 3, 4, 3', 5′-tetrahydroxybibenzyl (4) and piceatannol (5), were isolated from the wood of Streblus taxoides. Compound 4 showed a strong inhibitory activity against tyrosinase enzyme with an IC50 value of 35.65 µg/mL, followed by compound 2 with an IC50 value of 47.34 µg/mL. Conversely, compound 1, 3 and 5 showed moderate activity, with IC50 values of 109.64, 128.67 and 149.73 µg/mL, respectively. Moreover, compound 1 and 3 showed an antibacterial effect against some Staphylococcus spp. Thus, the isolated compounds exhibited potential antityrosine and antibacterial effects. Additionally, an in silico study was performed in order to predict theoretical molecular interactions between the obtained metabolites from S. taxoides and tyrosinase as an extended in vitro enzyme binding assay experiment.
- Subjects
PHENOL oxidase; ANTIBACTERIAL agents; MOLECULAR interactions; BINDING site assay; BACTERIAL diseases; NATURAL products
- Publication
Antibiotics (2079-6382), 2023, Vol 12, Issue 2, p319
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics12020319