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- Title
Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review.
- Authors
Araújo, Emmy Marjorie Carvalho de; Campos, Marcos Adriano Garcia; Sodré, Andressa Monteiro; Holanda, Maria Izabel de; Hagemann, Rodrigo; Teixeira Júnior, Antonio Augusto Lima; Salgado Filho, Natalino; Neves, Precil Diego Miranda de Menezes; Silva, Gyl Eanes Barros
- Abstract
Large-scale COVID-19 vaccination has been one of the most effective strategies to control the spread of the SARS-CoV-2 virus. However, several cases of glomerular injury related to the COVID-19 vaccine have been described in the literature. We report two cases of a tip lesion variant of focal segmental glomerulosclerosis (FSGS), which presented with significant proteinuria and improved after immunosuppression. In our literature review, the tip lesion variant of FSGS is currently the most frequent variant associated with vaccination against COVID-19. Prognosis is favorable and without significant alterations in the tubulointerstitial or vascular compartments. Adverse effects of vaccines need to be recognized early and will help us to understand the immune and pathological mechanisms of kidney damage.
- Subjects
LITERATURE reviews; COVID-19 vaccines; VACCINATION complications; SARS-CoV-2; PROGNOSIS; FOCAL segmental glomerulosclerosis
- Publication
Vaccines, 2024, Vol 12, Issue 1, p62
- ISSN
2076-393X
- Publication type
Case Study
- DOI
10.3390/vaccines12010062