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- Title
A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?
- Authors
Kim, Sung-Jae; Nguyen, Van-Giap; Park, Yong-Ho; Park, Bong-Kyun; Chung, Hee-Chun
- Abstract
The S glycoprotein of coronaviruses is important for viral entry and pathogenesis with most variable sequences. Therefore, we analyzed the S gene sequences of SARS-CoV-2 to better understand the antigenicity and immunogenicity of this virus in this study. In phylogenetic analysis, two subtypes (SARS-CoV-2a and -b) were confirmed within SARS-CoV-2 strains. These two subtypes were divided by a novel synonymous mutation of D614G. This may play a crucial role in the evolution of SARS-CoV-2 to evade the host immune system. The region containing this mutation point was confirmed as a B-cell epitope located in the S1 domain, and SARS-CoV-2b strains exhibited severe reduced antigenic indexes compared to SARS-CoV-2a in this area. This may allow these two subtypes to have different antigenicity. If the two subtypes have different serological characteristics, a vaccine for both subtypes will be more effective to prevent COVID-19. Thus, further study is urgently required to confirm the antigenicity of these two subtypes.
- Subjects
SARS-CoV-2; COVID-19; PATHOLOGY; CORONAVIRUSES; IMMUNE system
- Publication
Vaccines, 2020, Vol 8, Issue 2, p220
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines8020220