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- Title
Formulation and Characterization of Solid Lipid Nanoparticles Loaded with Troxerutin.
- Authors
Jamous, Yahya F.; Altwaijry, Najla A.; Saleem, Mohamed T. S.; Alrayes, Aljoharah F.; Albishi, Sara M.; Almeshari, Mashael A.
- Abstract
Troxerutin (TXR), a naturally derived compound with diverse therapeutic potential, faces limitations in clinical efficacy due to poor bioavailability and rapid plasma clearance. This study focuses on troxerutin-loaded solid lipid nanoparticles (TXR-SLNs) and their physicochemical properties, intending to enhance drug release. TXR-SLNs were prepared via high-shear homogenization followed by ultrasonication, yielding optimized nanoparticles with an average size of 140.5 ± 1.02 nm, a uniform distribution (polydispersity index: 0.218 ± 0.01), and a stable emulsion (zeta potential: 28 ± 8.71 mV). The formulation exhibited 83.62% entrapment efficiency, indicating improved drug-loading capacity and extended drug release. Spectroscopic and thermodynamic analyses confirmed component compatibility. Despite a decline in entrapment efficiency induced by temperature after one month of storage at 23 °C, the formulation may retain acceptable stability. This study provides insight into SLNs as effective carriers for enhancing troxerutin's release profile, motivating further in vivo investigations to optimize therapeutic interventions.
- Subjects
NANOPARTICLE size; NANOPARTICLES; ZETA potential; SOLIDS; SONICATION; LIPIDS
- Publication
Processes, 2023, Vol 11, Issue 10, p3039
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr11103039