We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Factors associated with recurrence of bleb-related infections.
- Authors
Ozawa, Kenji; Inuzuka, Masayuki; Murata, Kazuhiro; Ishihara, Takuma; Mochizuki, Kiyofumi; Sakaguchi, Hirokazu
- Abstract
Purpose: To identify the risk factors for a recurrence of a bleb-related infection (BRI). Study design: Retrospective cohort study. Methods: The medical records of all patients diagnosed with BRI at Gifu University Hospital between January 1989 and December 2020 were reviewed. The time when conjunctival hyperemia could not be detected and when the anterior chamber was quiet were defined as the resolution time of the BRI. The primary endpoint was a recurrence of a BRI. Kaplan-Meier estimation and the Cox proportional hazards model were used to determine the risk of a recurrence from the initial onset data of each eye. Bacteriological studies were performed to determine the pathogen causing the BRI. Results: There were 108 eyes of 103 patients followed for at least 3 months after the initial BRI. A recurrent bleb infection developed in 21 (19.4%) eyes of 21 patients (13 men, 8 women). Log-rank test at the 10-year follow-up examination revealed that hypotony at the onset of the BRI (P=0.004), the prophylactic use of topical antibiotics at the onset of the BRI (P=0.046), and bleb leakage after the resolution of the BRI (P=0.021) were significantly associated with a BRI recurrence. Cox proportional hazards model showed that ocular hypotony at the onset of the BRI (unadjusted, P=0.007; adjusted for bleb leakage, P=0.015) and bleb leakage after the resolution of the BRI (unadjusted, P=0.027; adjusted for hypotony, P=0.024) were significantly associated with a BRI recurrence. Other factors were not significantly associated with the recurrence of a BRI. Conclusion: We recommend close observations when a bleb leakage is detected after the BRI has resolved.
- Subjects
DISEASE relapse; PROPORTIONAL hazards models; OCULAR hypotony; LOG-rank test
- Publication
Japanese Journal of Ophthalmology, 2022, Vol 66, Issue 6, p559
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-022-00937-w