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- Title
Factors predicting the treatment frequency of ranibizumab injections during the second year in diabetic macular edema.
- Authors
Nishikawa, Keiichi; Murakami, Tomoaki; Ishihara, Kenji; Dodo, Yoko; Terada, Noriko; Morino, Kazuya; Tsujikawa, Akitaka
- Abstract
Purpose: To investigate the predictors of annual treatment frequency in the second year of pro re nata (PRN) intravitreal ranibizumab (IVR) injections for diabetic macular edema (DME). Study design: A retrospective study. Methods: We reviewed 65 eyes of 60 patients with center-involved DME who received PRN IVR injections after 3 monthly loading doses. The central subfield thickness (CST) and qualitative findings were assessed on the spectral domain optical coherence tomography (SD-OCT) images. We then investigated whether the parameters at the baseline or at the 12-month visit were associated with treatment frequency in the second year. Results: The number of ranibizumab injections decreased from 6 (4–8) during the first year to 2 (0–3) during the second year (P <.001). The injection numbers during the first year (ρ = 0.259, P =.037) but not during the second year (ρ = 0.152, P =.226) were modestly related to the logarithm of the minimum angle of resolution (logMAR) improvement at 24 months. Multivariate analyses revealed that the CST (β = 0.336, P =.005) and hyperreflective walls in the foveal cystoid spaces (β = 0.273, P =.020) at baseline were associated with the number of IVR injections during the second year. The treatment frequency during the second year was also related to the CST (β = 0.266, P =.012), hyperreflective walls (β = 0.394, P =.002), and cumulative doses of ranibizumab injections (β = 0.294, P =.006) at the 12-month visit. Conclusions: The cumulative doses of ranibizumab injections, CST, and hyperreflective walls in the foveal cystoid spaces at the 12-month visit are designated predictors of the treatment frequency of ranibizumab injections during the second year in DME.
- Subjects
MACULAR edema; RANIBIZUMAB; INJECTIONS; OPTICAL coherence tomography
- Publication
Japanese Journal of Ophthalmology, 2022, Vol 66, Issue 3, p296
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-022-00905-4