We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human immunodeficiency virus-related retinal microangiopathy and systemic cytomegalovirus disease association.
- Authors
Iwasaki, Yuko; Yamamoto, Narumichi; Kawaguchi, Tatsushi; Ozaki, Noriko; Tomita, Makoto; Ajisawa, Atsushi; Mochizuki, Manabu; Murakami, Kimio
- Abstract
Purpose: To determine whether there is a significant association between human immunodeficiency virus (HIV)-related retinal microangiopathy and systemic cytomegalovirus (CMV) disease in HIV-infected patients. Methods: Participants in this single-center, cross-sectional, retrospective study were 383 HIV-infected patients assessed for ocular manifestations before the beginning of antiretroviral therapy. The presence of HIV-related retinal microangiopathy, the presence of systemic CMV disease, laboratory data, and demographic information were determined by referring to medical records. The significance of any association between HIV-related retinal microangiopathy and systemic CMV disease was determined by use of the Chi-squared test and by multivariate analysis. Results: HIV-related retinal microangiopathy was present in 85 patients, and was significantly associated with systemic CMV disease both by use of the Chi-squared test ( P = 0.006) and by multivariate analysis ( P = 0.045, odds ratio 2.03, 95 % confidence interval 1.02-4.06 adjusted for CD4+ cell count and plasma HIV-RNA level). Conclusions: These findings indicate that microangiopathy may be involved in the development of CMV disease in HIV-infected patients. Thus, detection of the presence of HIV-related retinal microangiopathy is important in the management of HIV-infected patients.
- Subjects
HIV; HIV infections; CYTOMEGALOVIRUS diseases; MEDICAL care; RETINAL (Visual pigment); EYE diseases
- Publication
Japanese Journal of Ophthalmology, 2013, Vol 57, Issue 4, p372
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-013-0247-7