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- Title
Human herpesvirus 6-associated uveitis with optic neuritis diagnosed by multiplex PCR.
- Authors
Ogata, Nahoko; Koike, Naoko; Yoshikawa, Tadanobu; Takahashi, Kanji
- Abstract
Purpose: Human herpesvirus 6 (HHV-6), which is usually responsible for exanthem subitum in children, can be reactivated from its latent state. We report a case of unilateral optic disc edema and retinal vasculitis associated with HHV-6 infection. Case: A healthy 63-year-old man noted a decrease in the vision of his left eye. On examination, his left eye had moderate mutton-fat keratic precipitates, vitreous opacities, significant optic disc edema surrounded by yellowish-white swelling in the inner retina, retinal arteritis, and cotton-wool-like exudates. He was started on corticosteroid therapy and aspirin. After 1 month, the disc edema was reduced, the cotton wool-like exudates had decreased, and his visual acuity had improved to 10/20 OS. Multiplex polymerase chain reaction (PCR) of an aqueous humor sample revealed the presence of genomic DNA of HHV-6 but not of the other HHVs. Conclusions: The HHVs are known to infect the ocular tissues, but the differential diagnostic signs of HHV-6 are still not well known. We recommend that multiplex PCR of the aqueous humor be performed to search for the genomic DNA of HHV-6 in suspected cases of herpesviral infection.
- Subjects
HUMAN herpesvirus-6; ROSEOLA; JUVENILE diseases; VISION disorders; OLDER men; UVEITIS
- Publication
Japanese Journal of Ophthalmology, 2011, Vol 55, Issue 5, p502
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-011-0069-4