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- Title
Comparison of photopic negative responses elicited by red and white xenon flashes in monkeys.
- Authors
Kentaro Miyata; Shinji Ueno; Mineo Kondo; Toshiyuki Koyasu; Hiroko Terasaki
- Abstract
Abstract Purpose The photopic negative response (PhNR) is a negative component of the photopic electroretinogram (ERG), and is believed to originate mainly from the retinal ganglion cells. The PhNR is commonly elicited by red light-emitting diodes. The purpose of this study was to compare the amplitude of the PhNR elicited in monkeys by red stimuli and white stimuli obtained from a xenon light source. Methods The PhNRs were elicited from six rhesus monkeys by photopically matched red and white xenon flashes (peak output, 600 nm) on a rod-saturating blue background. The amplitudes of the PhNR elicited by white flashes were compared with those elicited by the red flashes before and after the intravitreal injection of tetrodotoxin (TTX). Results The differences in PhNR amplitudes between the red and white stimuli, and the changes in the PhNR amplitudes after the injection of TTX, were not statistically significant. Conclusion These results suggest that red and white xenon flashes are of approximately equal value for assessing inner retinal function using the PhNR under our recording conditions.
- Subjects
EYE diseases; RETINAL ganglion cells; LIGHT emitting diodes; RHESUS monkeys; TETRODOTOXIN; XENON; LIGHT sources; OPHTHALMOLOGY
- Publication
Japanese Journal of Ophthalmology, 2008, Vol 52, Issue 4, p327
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-008-0546-6