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- Title
Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density.
- Authors
Cawthorne, Christopher; Maguire, Paul; Mercier, Joel; Sciberras, David; Serdons, Kim; Bormans, Guy; de Hoon, Jan; Van Laere, Koen; Koole, Michel
- Abstract
Rationale: [11C]-UCB-J is an emerging tool for the noninvasive measurement of synaptic vesicle density in vivo. Here, we report human biodistribution and dosimetry estimates derived from sequential whole-body PET using two versions of the OLINDA dosimetry program. Methods: Sequential whole-body PET scans were performed in 3 healthy subjects for 2 h after injection of 254 ± 77 MBq [11C]-UCB-J. Volumes of interest were drawn over relevant source organs to generate time-activity curves and calculate time-integrated activity coefficients, with effective dose coefficients calculated using OLINDA 2.1 and compared to values derived from OLINDA 1.1 and those recently reported in the literature. Results: [11C]-UCB-J administration was safe and showed mixed renal and hepatobiliary clearance, with largest organ absorbed dose coefficients for the urinary bladder wall and small intestine (21.7 and 23.5 μGy/MBq, respectively). The average (±SD) effective dose coefficient was 5.4 ± 0.7 and 5.1 ± 0.8 μSv/MBq for OLINDA versions 1.1 and 2.1 respectively. Doses were lower than previously reported in the literature using either software version. Conclusions: A single IV administration of 370 MBq [11C]-UCB-J corresponds to an effective dose of less than 2.0 mSv, enabling multiple PET examinations to be carried out in the same subject. Trial registration: EudraCT number: 2016-001190-32. Registered 16 March 2016, no URL available for phase 1 trials.
- Subjects
RADIATION dosimetry; RADIOACTIVE tracers; POSITRON emission tomography; SYNAPTIC vesicles; BLADDER; ACTIVITY coefficients; DENSITY
- Publication
EJNMMI Physics, 2021, Vol 8, Issue 1, p1
- ISSN
2197-7364
- Publication type
Article
- DOI
10.1186/s40658-021-00384-5