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- Title
Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue.
- Authors
Wu, Jiaying; Li, Tuo; Guo, Meng; Ji, Junsong; Meng, Xiaoxi; Fu, Tianlong; Nie, Tengfei; Wei, Tongkun; Zhou, Ying; Dong, Weihua; Zhang, Ming; Shi, Yongquan; Cheng, Xin; Yin, Hao; Clinical Group; Mou, Xiaoyu; Feng, Yifan; Xu, Xiaoliang; Dong, Junfeng; He, Duowen
- Abstract
This article discusses a pilot study that investigated the use of personalized endoderm stem cell-derived islet tissue (E-islets) for the treatment of a type 2 diabetic patient with impaired pancreatic islet function. The patient underwent intrahepatic implantation of E-islets, which were generated from autologous endoderm stem cells. The study found that the E-islets were well-tolerated and resulted in significant improvements in glycemic control, with the patient experiencing a reduction in insulin requirements and improvements in fasting and meal-stimulated circulating C-peptide/insulin levels. The study suggests that stem cell-derived islet tissues may be an effective treatment option for late-stage type 2 diabetes patients.
- Subjects
ISLANDS of Langerhans; PEOPLE with diabetes; ISLANDS; CONTINUOUS glucose monitoring; ENDODERM; DEAD
- Publication
Cell Discovery, 2024, Vol 10, Issue 1, p1
- ISSN
2056-5968
- Publication type
Article
- DOI
10.1038/s41421-024-00662-3