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- Title
Common Bacterial Infections during the 3-Month Period after SARS-CoV-2 Infection: A Retrospective Cohort Study.
- Authors
Cohen, Bar; Shapiro Ben David, Shirley; Rahamim-Cohen, Daniella; Nakhleh, Afif; Shahar, Arnon; Yehoshua, Ilan; Bilitzky-Kopit, Avital; Azuri, Joseph; Mizrahi Reuveni, Miri; Adler, Limor
- Abstract
Introduction: Correlations between SARS-CoV-2 and bacterial infections have mainly been studied in hospitals, and these studies have shown that such interactions may be lethal for many. In the context of community flora, less is known of the trends and consequences of viral infections relative to subsequent bacterial infections. Purpose: This study aims to explore the prevalence and characteristics of bacterial infections in the three months following SARS-CoV-2 infections, in a community, real-world setting. Methods: In this retrospective cohort study, we compared patients who completed a polymerase chain reaction (PCR) test or an antigen test for SARS-CoV-2 during January 2022, the peak of the Omicron wave, and examined bacterial infections following the test. We searched these cases for diagnoses of the following four bacterial infections for three months following the test: Group A Streptococcus (GAS) pharyngitis, pneumonia, cellulitis, and urinary tract infections (UTI). Results: During January 2022, 267,931 patients tested positive and 261,909 tested negative for SARS-CoV-2. Test-positive compared to test-negative patients were significantly younger (42.5 years old vs. 48.5 years old, p < 0.001), smoked less, and had fewer comorbidities (including ischemic heart disease, diabetes mellitus, hypertension, chronic obstructive pulmonary disease, and chronic renal failure). In the multivariable analysis, test-positive patients had an increased risk for GAS pharyngitis (adjusted odds ratio [aOR] = 1.25, 95% CI 1.14–1.38, p-value < 0.001) and pneumonia (aOR = 1.25, 95% CI 1.15–1.35, p-value < 0.001), a trend towards an increased prevalence of UTI (aOR = 1.05, 95% CI 0.99–1.12, p-value = 0.092), and lower risk for cellulitis (aOR = 0.92, 95% CI 0.86–0.99, p-value < 0.05). Conclusions: A history of SARS-CoV-2 infection in the past three months increased susceptibility to respiratory tract bacterial infections and the prevalence of UTI.
- Subjects
BACTERIAL disease risk factors; COVID-19; CONFIDENCE intervals; MULTIVARIATE analysis; URINARY tract infections; RETROSPECTIVE studies; STREPTOCOCCAL diseases; GOODNESS-of-fit tests; RISK assessment; T-test (Statistics); DESCRIPTIVE statistics; POLYMERASE chain reaction; ODDS ratio; DATA analysis software; LOGISTIC regression analysis; LONGITUDINAL method
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 24, p3151
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11243151