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- Title
Microbial Biotransformation of Synthetic Hormone Drugs and Bioactivities of its Transformed Products.
- Authors
Anuar, Nur Amirah Khirul; Gazem, Mufeda Ahmed H.; Sultan, Sadia; Mohsin, Hannis Fadzilah; Shah, Syed Adnan Ali
- Abstract
Type 2 Diabetes Mellitus (T2DM) is often characterised by hyperglycemia, and the two inhibitors of thymidine phosphorylase and α-glucosidase are proven to help prevent T2DM. Steroids are widely known for their numerous medicinal uses, including potent α-glucosidase inhibitors. Microbial transformation is an effective method for creating new steroidal medicines from microorganisms, including yeasts, bacteria, and plant cells. It has been demonstrated that the approach may be used effectively to generate steroid-active pharmaceutical ingredients (APIs) and essential intermediates. This method has a naturally high yield outcome, is environment friendly and is a less time-consuming process that can synthesise steroid drugs more specifically. Estriol and 17-trenbolone were chosen since microbial transformation research on them is still ongoing.
- Subjects
SYNTHETIC drugs; BIOCONVERSION; TYPE 2 diabetes; STEROID drugs; ESTRIOL
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, p59
- ISSN
1675-8544
- Publication type
Article