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- Title
Malignant peripheral nerve sheath tumour with perineurial differentiation and hyaline eosinophilic globules (thanatosomes): A rare tumour.
- Authors
ABDELZAHER, Eman; ELWANY, Amr; AMR, Samir S.
- Abstract
Malignant peripheral nerve sheath tumour (MPNST) with perineurial differentiation is a rare variant of MPNST. The pathological features and clinical significance of this variant remain to be characterised. We reported the clinicoradiological and pathological features of a case of recurrent right arm mass related to the ulnar nerve in a 42-year-old female patient. On pathological examination, the tumour showed dual features of conventional and perineurial MPNST which was proven by positive immunostaining for S-100 and EMA. The pathological diagnosis was MPNST with perineurial differentiation. In addition, a peculiar and rare finding of intracytoplasmic eosinophilic hyaline globules (thanatosomes) within tumour cells is reported. We document a rare tumour with hybrid features between conventional and perineurial MPNSTs. Further studies are needed to establish its biological behaviour.
- Subjects
PERIPHERAL nerve tumors; HYALINE membrane disease; IMMUNOSTAINING; ULNAR nerve; NEUROFIBROMATOSIS 1
- Publication
Malaysian Journal of Pathology, 2018, Vol 40, Issue 3, p355
- ISSN
0126-8635
- Publication type
Case Study