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- Title
Spectrophotometric Determination of Salbutamol Sulphate and Isoxsuprine Hydrochloride in Pharmaceutical Formulations.
- Authors
Al Abdali, Zeena Z.; Habeeb, Nagham N.; Salih, Elham S.
- Abstract
A simple, sensitive and accurate spectrophotometric method has been developed for the determination of salbutamol sulphate (SAB) and isoxsuprine hydrochloride (ISX) in pure and pharmaceutical dosage. The method involved oxidation of (SAB) and (ISX) with a known excess of N-bromosuccinamid in acidic medium, and subsequent occupation of unreacted oxidant in decolorization of Evans blue dye (EB). This, in the presence of SAB or ISX was rectilinear over the ranges 1.0-12.0, 1.0-11.0 µg/mL, with molar absorptivity 4.21×104 and 2.58×104 l.mol-1 .cm-¹ respectively. The developed method had been successfully applied for the determination of the studied drugs in their pharmaceutical dosage resulting in a good agreement with certified value and standard addition procedure.
- Subjects
ALBUTEROL; SULFATES; DRUGS
- Publication
Baghdad Science Journal, 2023, Vol 20, Issue 2, p426
- ISSN
2078-8665
- Publication type
Article
- DOI
10.21123/bsj.2022.6902