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- Title
Supramolecular Arrangement and DFT analysis of Zinc(II) Schiff Bases: An Insight towards the Influence of Compartmental Ligands on Binding Interaction with Protein.
- Authors
Chowdhury, Megha Sen; Gumus, Selcuk; Dasgupta, Sanchari; Majumder, Ishani; Bhattacharya, Abir; Das, Debasis; Mukhopadhyay, Jayanta; Bose, Debosreeta; Dasgupta, Saumya; Akinay, Yuksel; Mukhopadhyay, Madhumita
- Abstract
We report, for the first time, a detailed crystallographic study of the supramolecular arrangement for a set of zinc(II) Schiff base complexes containing the ligand 2,6‐bis((E)‐((2‐(dimethylamino)ethyl)imino)methyl)‐4‐R‐phenol], where R=methyl/tert‐butyl/chloro. The supramolecular study acts as a pre‐screening tool for selecting the compartmental ligand R of the Schiff base for effective binding with a targeted protein, bovine serum albumin (BSA). The most stable hexagonal arrangement of the complex [Zn−Me] (R=Me) stabilises the ligand with the highest FMO energy gap (ΔE=4.22 eV) and lowest number of conformations during binding with BSA. In contrast, formation of unstable 3D columnar vertebra for [Zn−Cl] (R=Cl) tend to activate the system with lowest FMO gap (3.75 eV) with highest spontaneity factor in molecular docking. Molecular docking analyses reported in terms of 2D LigPlot+ identified site A, a cleft of domains IB, IIIA and IIIB, as the most probable protein binding site of BSA. Arg144, Glu424, Ser428, Ile455 and Lys114 form the most probable interactions irrespective of the type of compartmental ligands R of the Schiff base whereas Arg185, Glu519, His145, Ile522 act as the differentiating residues with ΔG=−7.3 kcal mol−1.
- Subjects
SCHIFF bases; CARRIER proteins; PROTEIN-protein interactions; PROTEIN binding; LIGANDS (Chemistry); BINDING sites; MOLECULAR docking; CHLORIDE channels
- Publication
ChemistryOpen, 2022, Vol 11, Issue 6, p1
- ISSN
2191-1363
- Publication type
Article
- DOI
10.1002/open.202200033