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- Title
Circulating Retinol-Binding Protein 4 Is Inversely Associated With Pancreatic β-Cell Function Across the Spectrum of Glycemia.
- Authors
Rong Huang; Songping Yin; Yongxin Ye; Nixuan Chen; Shiyun Luo; Min Xia; Lina Zhao; Huang, Rong; Yin, Songping; Ye, Yongxin; Chen, Nixuan; Luo, Shiyun; Xia, Min; Zhao, Lina
- Abstract
<bold>Objective: </bold>The aim of this study was to examine the association of circulating retinol-binding protein 4 (RBP4) levels with β-cell function across the spectrum of glucose tolerance from normal to overt type 2 diabetes.<bold>Research Design and Methods: </bold>A total of 291 subjects aged 35-60 years with normal glucose tolerance (NGT), newly diagnosed impaired fasting glucose or glucose tolerance (IFG/IGT), or type 2 diabetes were screened by a standard 2-h oral glucose tolerance test (OGTT) with the use of traditional measures to evaluate β-cell function. From these participants, 74 subjects were recruited for an oral minimal model test, and β-cell function was assessed with model-derived indices. Circulating RBP4 levels were measured by a commercially available ELISA kit.<bold>Results: </bold>Circulating RBP4 levels were significantly and inversely correlated with β-cell function indicated by the Stumvoll first-phase and second-phase insulin secretion indices, but not with HOMA of β-cell function, calculated from the 2-h OGTT in 291 subjects across the spectrum of glycemia. The inverse association was also observed in subjects involved in the oral minimal model test with β-cell function assessed by both direct measures and model-derived measures, after adjustment for potential confounders. Moreover, RBP4 emerged as an independent factor of the disposition index-total insulin secretion.<bold>Conclusions: </bold>Circulating RBP4 levels are inversely and independently correlated with β-cell function across the spectrum of glycemia, providing another possible explanation of the linkage between RBP4 and the pathogenesis of type 2 diabetes.
- Subjects
RETINOL-binding proteins; GLUCOSE tolerance tests; TYPE 2 diabetes; PATHOLOGY
- Publication
Diabetes Care, 2020, Vol 43, Issue 6, p1258
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc19-2432