We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reduction in keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide.
- Authors
Bchetnia, Mbarka; Lacroix, Jacynthe; Farez, Tarik; Larouche, Miriam; Powell, Julie; McCuaig, Catherine; Dupéré, Audrey; Morin, Charles; Legendre‐Guillemin, Valérie; Laprise, Catherine
- Abstract
The article discusses a study investigating the potential therapeutic effects of two chemical chaperones, trimethylamine N-oxide (TMAO) and sodium 4-phenylbutyrate (4-PBA), in the treatment of Epidermolysis bullosa simplex (EBS) by comparing keratin cytoskeleton abnormalities in cells of patients with EBS and non-EBS participants. It mentions that EBS is a skin disease caused by mutations in the keratin 5 (KRT5) or KRT14 genes. It mentions that TMAO reduces heat-induced keratin aggregates.
- Subjects
MOLECULAR chaperones; TRIMETHYLAMINE oxide; EPIDERMOLYSIS bullosa; PATIENTS; THERAPEUTICS
- Publication
Experimental Dermatology, 2016, Vol 25, Issue 3, p229
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12821