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- Title
Deletion of the Sox21 gene drastically affects hair lipids.
- Authors
Kawaminami, Shunro; Breakspear, Steven; Saga, Yumiko; Noecker, Bernd; Masukawa, Yoshinori; Tsuchiya, Masaru; Oguri, Masashi; Inoue, Yosuke; Ishikawa, Kazutaka; Okamoto, Masayuki
- Abstract
The effects of Sox21 gene deletion on hair lipids have been studied. For the cuticle-specific bound lipid 18-methyl eicosanoic acid (18- MEA), which was found to predominantly exist as the free form in Sox21−/− hair, total levels and distribution were unexpectedly unchanged. This indicates that while the biosynthesis of 18- MEA is unaffected, its covalent attachment to the cuticle surface is disrupted by loss of keratin-associated protein binding partners. Although the class compositions differed, the total ceramide ( CER) levels were found to be comparable between Sox21+/+ and Sox21−/− hairs. Deletion of the gene was also found to increase cholesterol sulphate ( CS) levels. The biosynthesis process might be associated with cuticle keratinocyte maturation, because both CS and CERs are known bioactives in keratinocyte differentiation.
- Subjects
LETTERS to the editor; LIPIDS; HAIR analysis
- Publication
Experimental Dermatology, 2012, Vol 21, Issue 12, p974
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12050