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- Title
Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus.
- Authors
Haas, N.; Schadendorf, D.; Henz, B.M.; Fuchs, P.G.
- Abstract
We describe a patient with a 9-year history of generalized eruptive keratoacanthoma (KA) of the Grzybowski type whose multiple skin lesions showed steady progression, resulting in a sclerotic, mask-like facial expression and ectropion. Eleven tumour biopsies representing lesions of different stages and localizations (erupting and regressing KAs, biopsies from non-involved light-protected and light-exposed skin, dermatosclerosis and squamous cell carcinomas) were analysed for human papillomavirus (HPV) sequences using a polymerase chain reaction approach capable of detecting the majority of all presently known HPV genotypes. None of the biopsy specimens proved to be HPV-positive, although HPV was detected in weakly and heavily affected control specimens by the method applied. These findings suggest an HPV-independent aetiology of this rare type of multiple KA.
- Subjects
KERATOACANTHOMA; PAPILLOMAVIRUSES
- Publication
British Journal of Dermatology, 2002, Vol 147, Issue 4, p793
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1046/j.1365-2133.2002.04925.x