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- Title
Toxicarioside O Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition by Downregulation of Trop2 in Lung Cancer Cells.
- Authors
Zheng, Wu-Ping; Huang, Feng-Ying; Dai, Shu-Zhen; Wang, Jin-Yan; Lin, Ying-Ying; Sun, Yan; Tan, Guang-Hong; Huang, Yong-Hao
- Abstract
Toxicarioside O (TCO), a natural product derived from Antiaris toxicaria , has been identified to be a promising anticancer agent. In this study, we aimed to investigate the effect of TCO on the proliferation and epithelial-mesenchymal transition (EMT) of lung cancer cells and its molecular mechanisms. Here, we indicated that TCO inhibits the proliferation of lung cancer cells both in vitro and in vivo. Our results demonstrated that TCO induces apoptosis in lung cancer cells. Moreover, we found that TCO suppresses EMT program and inhibits cell migration in vitro. Mechanistically, TCO decreases the expression of trophoblast cell surface antigen 2 (Trop2), resulting in inhibition of the PI3K/Akt pathway and EMT program. Overexpression of Trop2 rescues TCO-induced inhibition of cell proliferation and EMT. Our findings demonstrate that TCO markedly inhibits cell proliferation and EMT in lung cancer cells and provides guidance for its drug development.
- Subjects
EPITHELIAL-mesenchymal transition; CANCER cells; LUNG cancer; CELL proliferation; CELL surface antigens
- Publication
Frontiers in Oncology, 2021, Vol 11, pN.PAG
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2020.609275