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- Title
Dynamic Structural Transformation of Resveratrol-Modified Stearate Liposomes Led to a Spontaneous Drug Release System.
- Authors
Chen, Li-Chou; Lin, Shih-Shan; Li, Cun-Zhao; Hsu, Hsiu-Fu; Weng, Yu-Jong; Cheng, Chien-Chung
- Abstract
A mono-substituted resveratrol derivative, resveratrol-modified stearate (RMS), was synthesized by selectively coupling of stearic acid to the monohroxyphenyl of resveratrol in order to enhance both the stability and bioavailability of resveratrol. The RMS self-assembles into liposomes and a series of suprastructural transformations into metastable helical ribbon, linear wire-like structures, and inert spherical nanoparticles were detected that may be induced by the hydrogen-bonding interactions. As a model for drug-release investigations, gold nanoparticles (AuNPs) were encapsulated successfully by RMS to generate vesicles and succeed to release AuNPs druing the transformation to a ribbon-like metastable stucture at ambient temperature.
- Subjects
LIPOSOMES; RESVERATROL; STEARATES; DOSAGE forms of drugs; BIOAVAILABILITY
- Publication
Journal of the Chinese Chemical Society, 2013, Vol 60, Issue 9, p1099
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201300184