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- Title
Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.
- Authors
Ishikawa, Shinji; Kai, Mikio; Murata, Yasushi; Tamari, Mayumi; Daigo, Yataro; Murano, Takeshi; Ogawa, Michio; Nakamura, Y.
- Abstract
Abstract Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.
- Subjects
ACTIVIN; TRANSFORMING growth factors-beta; PEPTIDE hormones; HUMAN genome
- Publication
Journal of Human Genetics, 1998, Vol 43, Issue 2, p132
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050054