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- Title
Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin.
- Authors
Bukreyeva, Iryna; Angoulvant, Adela; Bendib, Inès; Gagnard, Jean-Charles; Bourhis, Jean-Henri; Dargère, Sylvie; Bonhomme, Julie; Thellier, Marc; Gachot, Bertrand; Wyplosz, Benjamin
- Abstract
Enterocytozoon bieneusi microsporidiosis is an emerging disease in immunocompromised patients. We report 2 cases of this disease in allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. Thrombocytopenia occurred but without major adverse events. Modifications of immunosuppression could be avoided when E. bieneusi is rapidly identified and fumagillin therapy is started promptly.
- Subjects
MICROSPORIDIOSIS; FUMAGILLIN; UNSATURATED fatty acids; STEM cell culture; PROGENITOR cells; FUNGI physiology; DIAGNOSIS; LEUKEMIA treatment; PREDNISONE; IMMUNOSUPPRESSIVE agents; MYCOPHENOLIC acid; ANTIFUNGAL agents; FUNGI; HEMATOPOIETIC stem cell transplantation; HYDROCARBONS; MYCOSES; THROMBOCYTOPENIA; MYELOID leukemia; TREATMENT effectiveness; PLATELET count; THERAPEUTICS
- Publication
Emerging Infectious Diseases, 2017, Vol 23, Issue 6, p1039
- ISSN
1080-6040
- Publication type
case study
- DOI
10.3201/eid2306.161825