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- Title
Clinical and Therapeutic Features of Pulmonary Nontuberculous Mycobacterial Disease, Brazil, 1993-2011.
- Authors
Couto de Mello, Karla Gripp; Queiroz Mello, Fernanda C.; Borga, Liamar; Rolla, Valeria; Duarte, Rafael S.; Sampaio, Elizabeth P.; Holland, Steven M.; Prevots, D. Rebecca; Dalcolmo, Margareth P.
- Abstract
To identify clinical and therapeutic features of pulmonary nontuberculous mycobacterial (PNTM) disease, we conducted a retrospective analysis of patients referred to the Brazilian reference center, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, who received a diagnosis of PNTM during 1993-2011 with at least 1 respiratory culture positive for NTM. Associated conditions included bronchiectasis (21.8%), chronic obstructive pulmonary disease (20.7%), cardiovascular disease (15.5%), AIDS (9.8%), diabetes (9.8%), and hepatitis C (4.6%). Two patients had Hansen disease; 1 had Marfan syndrome. Four mycobacterial species comprised 85.6% of NTM infections: Mycobacterium kansasii, 59 cases (33.9%); M. avium complex, 53 (30.4%); M. abscessus, 23 (13.2%); and M. fortuitum, 14 (8.0%). A total of 42 (24.1%) cases were associated with rapidly growing mycobacteria. In countries with a high prevalence of tuberculosis, PNTM is likely misdiagnosed as tuberculosis, thus showing the need for improved capacity to diagnose mycobacterial disease as well as greater awareness of PNTM disease prevalence.
- Subjects
BRAZIL; MYCOBACTERIAL diseases; LUNG diseases; CLINICAL medicine; THERAPEUTICS; COMMUNICABLE diseases
- Publication
Emerging Infectious Diseases, 2013, Vol 19, Issue 3, p393
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1903.120735