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- Title
Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures.
- Authors
Gray, Patricia; Hoppes, Sharman; Suchodolski, Paulette; Mirhosseini, Negin; Payne, Susan; Villanueva, Itamar; Shivaprasad, H. L.; Honkavuori, Kirsi S.; Briese, Thomas; Reddy, Sanjay M.; Tizard, Ian
- Abstract
Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). We successfully isolated and characterized ABV from the brains of 8 birds with confirmed PDD. One isolate was passed 6 times in duck embryo fibroblasts, and the infected cells were then injected intramuscularly into 2 healthy Patagonian conures (Cyanoliseus patagonis). Clinical PDD developed in both birds by 66 days postinfection. PDD was confirmed by necropsy and histopathologic examination. Reverse transcription-PCR showed that the inoculated ABV was in the brains of the 2 infected birds. A control bird that received uninfected tissue culture cells remained healthy until it was euthanized at 77 days, Necropsy and histopathologic examinations showed no abnormalities; PCR did not indicate ABV in its brain tissues.
- Subjects
VIRUS diseases in poultry; BIRDS as carriers of disease; CONURES; NEUROLOGY; INFECTION; CYANOLISEUS patagonus
- Publication
Emerging Infectious Diseases, 2010, Vol 16, Issue 3, p473
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1603.091257