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- Title
Three-dimensional power Doppler ultrasound for the study of cervical cancer and precancerous lesions.
- Authors
BELITSOS, P.; PAPOUTSIS, D.; RODOLAKIS, A.; MESOGITIS, S.; ANTSAKLIS, A.
- Abstract
Objective To evaluate the blood FIow characteristics of the cervix in normal women and in women with cervical precancerous lesions or cervical cancer. Methods We studied 165 women with three-dimensional power Doppler ultrasound (3D-PD U), of whom 71 had cervical cancer, 61 had precancerous lesions and 33 were healthy controls. The cervix was manually traced in the stored volumes using 15° rotation steps and the following 3D-PD U indices were calculated: vascularization index (VI), FIow index (FI) and vascularization FIow index (VFI). These indices were compared among the study groups and were also correlated with features of the precancerous lesions group and cancer group. Results The three indices were all statistically significantly higher in the cervical cancer group and precancerous lesions group than in controls (P < 0.001). In addition, significantly higher values of all indices were found in the cervical cancer group than in the precancerous lesions group (P < 0.001). Further analysis according to patient characteristics in the cancer group showed that VI, FI and VFI were not significantly different in relation to grade, histology, presence of positive lymph nodes or lymphovascular space involvement (P> 0.05). However, VI was significantly higher in patients with Stages IIIB -I V cancer than in patients with less advanced disease (P = 0.045). In the cervical cancer group there was a significant positive correlation between 3D-PD U indices and cervical volume. Conclusion 3D-PD U assessment of the cervix reveals significant differences in all indices studied between women with cervical precancerous lesions or cancer and healthy women. In women with cervical cancer, an advanced stage is associated with higher VI, but 3D-PD U indices are not related to other pathological characteristics.
- Subjects
CERVICAL cancer; DOPPLER ultrasonography; PRECANCEROUS conditions; BLOOD flow; LYMPH nodes
- Publication
Ultrasound in Obstetrics & Gynecology, 2012, Vol 40, Issue 5, p576
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.11134