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- Title
Ginsenosides are Promising Medicine for Tumor and Inflammation: A Review.
- Authors
Li, Jiawei; Li, Fangfang; Jin, Dan
- Abstract
Ginseng is a valuable medicinal plant in Asian countries with thousands of years of history. Ginsenosides, one of the active components of ginseng, are considered to be of potential value in the treatment of various diseases. The antitumor effects of ginsenosides, such as Rg3, Rh2, Rg5, and CK, are well known, and their potential mechanisms are thought to be related to inducing apoptosis, enhancing the immune response, reversing drug resistance to chemotherapy, and regulating signaling pathways, such as MAPK, PI3K/Akt/mTOR, Wnt/ β -catenin, NF- κ B, ASK-1/JNK, AMPK, and EGFR/Akt/SOX2. On the other hand, ginsenosides also have anti-inflammatory effects, including reducing the release of inflammatory factors, regulating the balance of immune cells, regulating the diversity of intestinal flora, and activating MAPK, NF- κ B, and NLRP3 inflammasomes. These data suggest that ginsenosides may provide new insights as promising drugs for the treatment of malignant tumors and inflammatory diseases.
- Subjects
ASIA; DISEASE progression; INTERLEUKINS; IMMUNE checkpoint inhibitors; INFLAMMATION; ANTI-inflammatory agents; GUT microbiome; GLYCOSIDES; ANTINEOPLASTIC agents; APOPTOSIS; DRUG resistance; NF-kappa B; METASTASIS; IMMUNE system; CELL physiology; TREATMENT effectiveness; CELLULAR signal transduction; GENE expression profiling; TUMOR necrosis factors; PLANT extracts; TUMORS; MOLECULAR structure; VASCULAR endothelial growth factors; CELL lines; MITOGEN-activated protein kinases; IMMUNOTHERAPY; CHEMICAL inhibitors
- Publication
American Journal of Chinese Medicine, 2023, Vol 51, Issue 4, p883
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X23500416