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- Title
Effects of chronic administration of adipokinetic and hypertrehalosemic hormone on animal behavior, BDNF, and CREB expression in the hippocampus and neurogenesis in mice.
- Authors
Mutlu, Oguz; Gumuslu, Esen; Kokturk, Sibel; Ulak, Guner; Akar, Furuzan; Erden, Faruk; Kaya, Havva; Tanyeri, Pelin
- Abstract
Neurosecretory cells in corpus cardiacum of insects synthesize a set of hormones that are called adipokinetic, hypertrehalosaemic or hyperprolinaemic, depending on insect in question. This study investigated effects of chronic administration of Anax imperator adipokinetic hormone (Ani- AKH), Libellula auripennis adipokinetic hormone (Lia- AKH), and Phormia-Terra hypertrehalosaemic hormone (Pht-Hr TH) on depression, anxiety, analgesy, locomotion in forced swimming ( FST), elevated plus-maze ( EPM), hot plate, and locomotor activity tests. Ani- AKH (1 and 2 mg/kg), Lia- AKH (1 and 2 mg/kg), and Pht-Hr TH (1 and 2 mg/kg) had antidepressant effects in forced swimming test. Lia- AKH (2 mg/kg) and Pht-Hr TH (1 and 2 mg/kg) had anxiolytic effects when given chronically in elevated plus-maze test. Ani- AKH (1 and 2 mg/kg) and Pht-Hr TH (2 mg/kg) had antinociceptive effects in hot plate test in male balb-c mice. Ani- AKH (2 mg/kg), Lia- AKH (1 and 2 mg/kg), and Pht-Hr TH had locomotion-enhancing effects in locomotor activity test in male balb-c mice. Drug treatment significantly increased brain-derived neurotrophic factor ( BDNF) and cyclic adenosine monophosphate ( cAMP) response element binding protein ( CREB) gene expression levels compared to control levels. Pht-Hr TH and Ani- AKH groups had significantly increased numbers of BrdU-labeled cells, while neurodegeneration was lower in the Pht-Hr TH group. Our study showed that AKH/ RPCH family peptides may be used in treatment of psychiatric illness such as depression and anxiety, in treatment of pain and in diseases related to locomotion system. AKH/ RPCH family peptides increase neurotrophic factors in brain and have potential proliferative and neuroprotective effects in hippocampal neurogenesis and neurodegeneration.
- Subjects
ADIPOKINETIC hormone; ANIMAL behavior; DEVELOPMENTAL neurobiology; HIPPOCAMPUS (Brain); NEUROSECRETION
- Publication
Fundamental & Clinical Pharmacology, 2016, Vol 30, Issue 1, p4
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1111/fcp.12165