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- Title
Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs.
- Authors
Kantar, Cihan; Baltaş, Nimet; Karaoğlu, Şengül Alpay; Şaşmaz, Selami
- Abstract
To improve and develop our monotherapeutic approach for Helicobacter pylori infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, and Anti-Helicobacter pylori effect were investigated and compared with azo analogs in the literature. All Schiff base compounds have been found to have both stronger urease enzyme inhibitory and more effective Anti-Helicobacter pylori properties than its azo analogs. In particular, the antimicrobial effect of Schiff bases containing eugenol increased dramatically when compared to their azo analogs.
- Subjects
UREASE; GUAIACOL; HELICOBACTER pylori infections; EUGENOL; SCHIFF bases; OXIDANT status
- Publication
Pharmaceutical Chemistry Journal, 2024, Vol 57, Issue 11, p1738
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-024-03074-5